Ruth Brenk : rechercher sur Z-Library

Année:

2011

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2011

In silico identification and experimental validation of hits active against KPC-2 β-lactamase

Klein, Raphael, Linciano, Pasquale, Celenza, Giuseppe, Bellio, Pierangelo, Papaioannou, Sofia, Blazquez, Jesus, Cendron, Laura, Brenk, Ruth, Tondi, Donatella, Lodola, Alessio

Journal:

Emmanuel A. Meyer, Ruth Brenk, Ronald K. Castellano, Maya Furler, Gerhard Klebe, François Diederich

Année:

2018

Langue:

english

Fichier:

PDF, 3.31 MB

english, 2018

De Novo Design, Synthesis, and In Vitro Evaluation of Inhibitors for Prokaryotic tRNA-Guanine Transglycosylase: A Dramatic Sulfur Effect on Binding Affinity

Journal:

ChemBioChem

Année:

2002

Langue:

english

Fichier:

PDF, 112 KB

english, 2002

Flexible Adaptations in the Structure of the tRNA-Modifying Enzyme tRNA–Guanine Transglycosylase and Their Implications for Substrate Selectivity, Reaction Mechanism and Structure-Based Drug Design

Ruth Brenk, Milton T. Stubbs, Andreas Heine, Klaus Reuter, Gerhard Klebe

Journal:

ChemBioChem

Année:

2003

Langue:

english

Fichier:

PDF, 384 KB

english, 2003

ChemInform Abstract: De Novo Design, Synthesis, and in vitro Evaluation of Inhibitors for Prokaryotic tRNA-Guanine Transglycosylase: A Dramatic Sulfur Effect on Binding Affinity.

Emmanuel A. Meyer, Ruth Brenk, Ronald K. Castellano, Maya Furler, Gerhard Klebe, Francois Diederich

Journal:

ChemInform

Année:

2002

Fichier:

PDF, 26 KB

2002

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

Ruth Brenk, Alessandro Schipani, Daniel James, Agata Krasowski, Ian Hugh Gilbert, Julie Frearson, Paul Graham Wyatt

Journal:

Daniel Spinks, Dr. Han B. Ong, Dr. Chidochangu P. Mpamhanga, Dr. Emma J. Shanks, Dr. David A. Robinson, Iain T. Collie, Dr. Kevin D. Read, Prof. Julie A. Frearson, Prof. Paul G. Wyatt, Dr. Ruth Brenk,

Année:

2008

Langue:

english

Fichier:

PDF, 603 KB

english, 2008

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

Journal:

Victoria C. Smith, Dr. Laura A. T. Cleghorn, Dr. Andrew Woodland, Daniel Spinks, Irene Hallyburton, Iain T. Collie, Dr. N. Yi Mok, Suzanne Norval, Dr. Ruth Brenk, Prof. Alan H. Fairlamb, Prof. Julie A

Année:

2011

Langue:

english

Fichier:

PDF, 526 KB

english, 2011

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

Journal:

Ruth Brenk, Hans-Dieter Gerber, Jeffrey D. Kittendorf, George A. Garcia, Klaus Reuter, Gerhard Klebe

Année:

2011

Langue:

english

Fichier:

PDF, 291 KB

english, 2011

From Hit to Lead: De Novo Design Based on Virtual Screening Hits of Inhibitors of tRNA-Guanine Transglycosylase, a Putative Target of Shigellosis Therapy

Journal:

Helvetica Chimica Acta

Année:

2003

Langue:

english

Fichier:

PDF, 299 KB

english, 2003

Synthesis and In Vitro Evaluation of 2-Aminoquinazolin-4(3H)-one-Based Inhibitors for tRNA-Guanine Transglycosylase (TGT)

Emmanuel A. Meyer, Maya Furler, François Diederich, Ruth Brenk, Gerhard Klebe

Journal:

Helvetica Chimica Acta

Année:

2004

Langue:

english

Fichier:

PDF, 395 KB

english, 2004

Synthesis, Biological Evaluation, and Crystallographic Studies of Extended Guanine-Based (lin-Benzoguanine) Inhibitors for tRNA-Guanine Transglycosylase (TGT)

Emmanuel A. Meyer, Nicola Donati, Marine Guillot, W. Bernd Schweizer, François Diederich, Bernhard Stengl, Ruth Brenk, Klaus Reuter, Gerhard Klebe

Journal:

Helvetica Chimica Acta

Année:

2006

Langue:

english

Fichier:

PDF, 769 KB

english, 2006

Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase

Gian Filippo Ruda, Gordon Campbell, Vincent P. Alibu, Michael P. Barrett, Ruth Brenk, Ian H. Gilbert

Journal:

Bioorganic & Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2010

Identification of novel inhibitors of UDP-Glc 4′-epimerase, a validated drug target for african sleeping sickness

Michael D. Urbaniak, Jioji N. Tabudravu, Aichi Msaki, Kathy Mansfield Matera, Ruth Brenk, Marcel Jaspars, Michael A.J. Ferguson

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 225 KB

english, 2006

Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking

Peter Daldrop, Francis E. Reyes, David A. Robinson, Colin M. Hammond, David M. Lilley, Robert T. Batey, Ruth Brenk

Journal:

Chemistry & Biology

Année:

2011

Langue:

english

Fichier:

PDF, 807 KB

english, 2011

Effect of High Oxygen Pressure on the Protective Action of Cystamine and 5-Hydroxytryptamine in Irradiated Rats

VAN DEN BRENK, H. A. S., MOORE, RUTH

Journal:

Nature

Année:

1959

Fichier:

PDF, 223 KB

1959

Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry

Bhat, Venugopal T., Caniard, Anne M., Luksch, Torsten, Brenk, Ruth, Campopiano, Dominic J., Greaney, Michael F.

Journal:

Nature Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2010

Nucleosomes can invade DNA territories occupied by their neighbors

Engeholm, Maik, de Jager, Martijn, Flaus, Andrew, Brenk, Ruth, van Noort, John, Owen-Hughes, Tom

Journal:

Nature Structural and Molecular Biology

Année:

2009

Langue:

english

Fichier:

PDF, 832 KB

english, 2009

Change or be changed: Reflections of the workshop ‘Future in Medicinal Chemistry’

Ruth Brenk, Daniel Rauh

Journal:

Bioorganic & Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 132 KB

english, 2012

Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening

Ruth Brenk, EmmanuelA. Meyer, Klaus Reuter, Milton T. Stubbs, George A. Garcia, François Diederich, Gerhard Klebe

Journal:

Ruth Brenk, Stefan W. Vetter, Sarah E. Boyce, David B. Goodin, Brian K. Shoichet

Année:

2004

Langue:

english

Fichier:

PDF, 5.39 MB

english, 2004

Probing Molecular Docking in a Charged Model Binding Site

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2006

Crystal Structures of tRNA-guanine Transglycosylase (TGT) in Complex with Novel and Potent Inhibitors Unravel Pronounced Induced-fit Adaptations and Suggest Dimer Formation Upon Substrate Binding

Bernhard Stengl, Emmanuel A. Meyer, Andreas Heine, Ruth Brenk, François Diederich, Gerhard Klebe

Journal:

June Uren, Ruth Moore, H.A.S. Van Den Brenk

Année:

2007

Langue:

english

Fichier:

PDF, 3.00 MB

english, 2007

Development of a pseudodiploid cell line, JU56, of wallaby fibroblasts

Journal:

Experimental Cell Research

Année:

1966

Langue:

english

Fichier:

PDF, 1.95 MB

english, 1966

Design, Synthesis, and Biological Evaluation of 3,4-Diarylmaleimides as Angiogenesis Inhibitors

Peifer, Christian, Stoiber, Thomas, Unger, Eberhard, Totzke, Frank, Schächtele, Christoph, Marmé, Dieter, Brenk, Ruth, Klebe, Gerhard, Schollmeyer, Dieter, Dannhardt, Gerd

Journal:

Cappel, Daniel, Wahlström, Rickard, Brenk, Ruth, Sotriffer, Christoph A.

Année:

2006

Langue:

english

Fichier:

PDF, 482 KB

english, 2006

De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

Urich, Robert, Wishart, Grant, Kiczun, Michael, Richters, André, Tidten-Luksch, Naomi, Rauh, Daniel, Sherborne, Brad, Wyatt, Paul G., Brenk, Ruth

Journal:

ACS Chemical Biology

Année:

2013

Langue:

english

Fichier:

PDF, 3.18 MB

english, 2013

Probing the Dynamic Nature of Water Molecules and Their Influences on Ligand Binding in a Model Binding Site

Journal:

Michelle Vincendeau, Daniel Nagel, Jara K Brenke, Ruth Brack-Werner…

Année:

2011

Langue:

english

Fichier:

PDF, 3.72 MB

english, 2011

Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts

Journal:

Virology Journal

Année:

2013

Langue:

english

Fichier:

PDF, 325 KB

english, 2013

Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

Alphey, Magnus S., Pirrie, Lisa, Torrie, Leah S., Boulkeroua, Wassila Abdelli, Gardiner, Mary, Sarkar, Aurijit, Maringer, Marko, Oehlmann, Wulf, Brenk, Ruth, Scherman, Michael S., McNeil, Michael, Rej

Journal:

ACS Chemical Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.66 MB

english, 2013

Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening

Mok, N. Yi, Brenk, Ruth, Brown, Nathan

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2014

Mining the ChEMBL Database: An Efficient Chemoinformatics Workflow for Assembling an Ion Channel-Focused Screening Library

Mok, N. Yi, Brenk, Ruth

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 2.10 MB

english, 2011

Structural Insights into the Mechanism and Inhibition of the β-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonas aeruginosa

Moynié, Lucile, Leckie, Stuart M., McMahon, Stephen A., Duthie, Fraser G., Koehnke, Alessa, Taylor, James W., Alphey, Magnus S., Brenk, Ruth, Smith, Andrew D., Naismith, James H.

Journal:

Urich, Robert, Grimaldi, Raffaella, Luksch, Torsten, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G.

Année:

2013

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2013

The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis

Journal:

Ramsden, Nicola L., Buetow, Lori, Dawson, Alice, Kemp, Lauris A., Ulaganathan, Venkatsubramanian, Brenk, Ruth, Klebe, Gerhard, Hunter, William N.

Année:

2014

Langue:

english

Fichier:

PDF, 5.47 MB

english, 2014

A Structure-Based Approach to Ligand Discovery for 2 C -Methyl- d -erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy †

Journal:

Graves, Alan P., Brenk, Ruth, Shoichet, Brian K.

Année:

2009

Langue:

english

Fichier:

PDF, 1.79 MB

english, 2009

Decoys for Docking

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 897 KB

english, 2005

Virtual Screening for Submicromolar Leads of tRNA-guanine Transglycosylase Based on a New Unexpected Binding Mode Detected by Crystal Structure Analysis

Brenk, Ruth, Naerum, Lars, Grädler, Ulrich, Gerber, Hans-Dieter, Garcia, George A., Reuter, Klaus, Stubbs, Milton T., Klebe, Gerhard

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 889 KB

english, 2003

Locating Sweet Spots for Screening Hits and Evaluating Pan-Assay Interference Filters from the Performance Analysis of Two Lead-like Libraries

Mok, N. Yi, Maxe, Sara, Brenk, Ruth

Journal:

Lucas-Lopez, Cristina, Allingham, John S., Lebl, Tomas, Lawson, Christopher P. A. T., Brenk, Ruth, Sellers, James R., Rayment, Ivan, Westwood, Nicholas J.

Année:

2013

Langue:

english

Fichier:

PDF, 3.44 MB

english, 2013

The small molecule tool (S)-(−)-blebbistatin: novel insights of relevance to myosin inhibitor design

Journal:

Organic & Biomolecular Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 480 KB

english, 2008

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules

Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A. T., Ojo, Kayode K., Van Voorhis, Wesley C., Brenk, Ruth, Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G.

Journal:

Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A. T., Ojo, Kayode K., Van Voorhis, Wesley C., Brenk, Ruth, Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G.

Année:

2013

Langue:

english

Fichier:

PDF, 1.57 MB

english, 2013

Back Cover: From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules (ChemMedChem 7/2013)

Journal:

Rekand, Illimar Hugo, Brenk, Ruth

Année:

2013

Fichier:

PDF, 876 KB

2013

Ligand design for riboswitches, an emerging target class for novel antibiotics

Journal:

Future Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2017

Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form

Baum, Bernhard, Lecker, Laura S. M., Zoltner, Martin, Jaenicke, Elmar, Schnell, Robert, Hunter, William N., Brenk, Ruth

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2015

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2015

Design and Synthesis of Brain Penetrant Trypanocidal N -Myristoyltransferase Inhibitors

Bayliss, Tracy, Robinson, David A., Smith, Victoria C., Brand, Stephen, McElroy, Stuart P, Torrie, Leah S., Mpamhanga, Chido, Norval, Suzanne, Stojanovski, Laste, Brenk, Ruth, Frearson, Julie A, Read,

Journal:

Tidten-Luksch, Naomi, Grimaldi, Raffaella, Torrie, Leah S., Frearson, Julie A., Hunter, William N., Brenk, Ruth, Campos-Olivas, Ramón

Année:

2017

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2017

IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2012

Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design

Irsheid, Lina, Wehler, Thomas, Borek, Christoph, Kiefer, Werner, Brenk, Ruth, Ortiz-Soto, Maria Elena, Seibel, Jürgen, Schirmeister, Tanja, Silman, Israel

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 2.39 MB

english, 2019

Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design

Irsheid, Lina, Wehler, Thomas, Borek, Christoph, Kiefer, Werner, Brenk, Ruth, Ortiz-Soto, Maria Elena, Seibel, Jürgen, Schirmeister, Tanja, Silman, Israel

Journal:

Kersten, Christian, Fleischer, Edmond, Kehrein, Josef, Borek, Christoph, Jaenicke, Elmar, Sotriffer, Christoph, Brenk, Ruth

Année:

2019

Fichier:

PDF, 2.39 MB

2019

How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N -Myristoyltransferases as a Model System

Journal: